An emerging role for p21-activated kinases (Paks) in viral infections

Trends Cell Biol. 2010 Mar;20(3):160-9. doi: 10.1016/j.tcb.2009.12.005. Epub 2010 Jan 12.

Abstract

p21-activated protein kinases (Paks) are cytosolic serine/threonine protein kinases that act as effectors for small (p21) GTPases of the Cdc42 and Rac families. It has long been established that Paks play a major role in a host of vital cellular functions such as proliferation, survival and motility, and abnormal Pak function is associated with a number of human diseases. Here, we discuss emerging evidence that these enzymes also play a major role in the entry, replication and spread of many important pathogenic human viruses, including HIV. Careful assessment of the potential role of Paks in antiviral immunity will be pivotal to evaluate thoroughly the potential of agents that inhibit Pak as a new class of anti-viral therapeutics.

Publication types

  • Review

MeSH terms

  • Adenoviridae / physiology
  • Amino Acid Motifs
  • Amino Acid Sequence
  • Apoptosis / physiology
  • Enzyme Activation
  • Gene Products, nef / physiology
  • Hepadnaviridae / physiology
  • Herpesviridae / physiology
  • Humans
  • Molecular Sequence Data
  • Poxviridae / physiology
  • Sequence Alignment
  • Virus Diseases / physiopathology*
  • Virus Internalization
  • Virus Replication / physiology
  • p21-Activated Kinases / physiology*

Substances

  • Gene Products, nef
  • PAK1 protein, human
  • PAK2 protein, human
  • p21-Activated Kinases