Design strategies for the creation of artificial metalloenzymes

Tillmann Heinisch; Thomas R Ward

doi:10.1016/j.cbpa.2009.11.026

Design strategies for the creation of artificial metalloenzymes

Curr Opin Chem Biol. 2010 Apr;14(2):184-99. doi: 10.1016/j.cbpa.2009.11.026. Epub 2010 Jan 12.

Authors

Tillmann Heinisch¹, Thomas R Ward

Affiliation

¹ Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland.

PMID: 20071213
DOI: 10.1016/j.cbpa.2009.11.026

Abstract

In recent years, several complementary strategies have been implemented for the creation and optimization of artificial metalloenzymes. Selected examples outline the pros and cons of five different approaches: catalytic antibodies, computational design, directed evolution, artificial metal-cofactors and DNAzymes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Amino Acid Sequence
Animals
Biomimetics / methods*
Computational Biology / methods*
Humans
Metalloproteins / chemistry
Metalloproteins / genetics
Metalloproteins / metabolism*
Models, Molecular
Molecular Sequence Data

Substances

Metalloproteins