Preimplantation genetic diagnosis (PGD) for HLA typing: bases for setting up an open international collaboration when PGD is not available

Fertil Steril. 2010 Aug;94(3):1129-31. doi: 10.1016/j.fertnstert.2009.11.007. Epub 2010 Jan 13.

Abstract

In severe forms of Diamond-Blackfan anemia, preimplantation genetic diagnosis (PGD) of histocompatibility leukocyte antigen-compatible embryos for enabling the next sibling in the family to be a stem-cell transplantation donor constitutes the sole lasting cure capable of terminating the enduring need for iterative transfusions. We report here an open collaboration between two renowned institutions to provide a family desiring this treatment even though they resided where the preimplantation genetic diagnosis procedure is banned.

Publication types

  • Case Reports
  • Multicenter Study

MeSH terms

  • Adult
  • Anemia, Diamond-Blackfan / therapy
  • Child
  • Directed Tissue Donation / legislation & jurisprudence
  • Female
  • Fertilization in Vitro
  • Health Services Accessibility* / legislation & jurisprudence
  • Histocompatibility Testing / methods*
  • Humans
  • International Cooperation*
  • Pregnancy
  • Preimplantation Diagnosis / methods
  • Preimplantation Diagnosis / statistics & numerical data*
  • Sibling Relations
  • Siblings
  • Stem Cell Transplantation / methods
  • Switzerland
  • Transplantation, Homologous