Etoposide (VP 16-213) induced hepatitis. Report of three cases following standard-dose treatments

J Hepatol. 1991 Jan;12(1):36-9. doi: 10.1016/0168-8278(91)90905-q.

Abstract

Acute hepatitis is a potential, although rare, complication following administration of high doses of Etoposide (VP 16-213). We report three cases of severe hepatocellular necrosis following administration of standard doses of this antineoplastic agent.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Aged
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use
  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / pathology
  • Dose-Response Relationship, Drug
  • Etoposide / administration & dosage
  • Etoposide / adverse effects*
  • Etoposide / therapeutic use
  • Female
  • Humans
  • Liver / drug effects
  • Liver / pathology
  • Male
  • Middle Aged
  • Necrosis / chemically induced
  • Necrosis / pathology
  • Neoplasms / drug therapy

Substances

  • Antineoplastic Agents
  • Etoposide