MK2 signaling: lessons on tissue specificity in modulation of inflammation

Nanna Fyhrquist; Sampsa Matikainen; Antti Lauerma

doi:10.1038/jid.2009.372

MK2 signaling: lessons on tissue specificity in modulation of inflammation

J Invest Dermatol. 2010 Feb;130(2):342-4. doi: 10.1038/jid.2009.372.

Authors

Nanna Fyhrquist¹, Sampsa Matikainen, Antti Lauerma

Affiliation

¹ Unit of Excellence in Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland.

PMID: 20081887
DOI: 10.1038/jid.2009.372

Abstract

MK2 is a promising candidate for treating inflammation. Mice deficient in MK2 were studied in models of inflammation to see whether MK2 could be a useful target in inflammatory skin disease. Surprisingly, MK2 played only a minor role in skin inflammation, indicating that modulation of cell signaling gives different results depending on the models of inflammation and target organs that are studied.

Publication types

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MeSH terms

Animals
Gene Expression Regulation
Humans
Inflammation / genetics*
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / physiology*
Mice
Models, Biological
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / physiology*
Signal Transduction
Skin / metabolism*
Skin Physiological Phenomena
p38 Mitogen-Activated Protein Kinases / metabolism

Substances

Intracellular Signaling Peptides and Proteins
MAP-kinase-activated kinase 2
Protein Serine-Threonine Kinases
p38 Mitogen-Activated Protein Kinases