Women rule

Surgery. 2010 Jan;147(1):134-7. doi: 10.1016/j.surg.2009.04.033.

Abstract

Female animals tolerate trauma and hemorrhage better than male animals AND Estrogen has rapid nongenomic effects that protect organs from damage and attenuate insult-induced inflammation MOREOVER The survival deficit from trauma and hemorrhage produced in ovariectomized female animals is repaired with administration of exogenous estrogen AND Women survive injury, sepsis, and trauma-hemorrhage-induced hypoxemia/reperfusion better than men THEREFORE Women rule ... in survival after trauma, thus, men would benefit from being more like women.

MeSH terms

  • Animals
  • Estradiol / pharmacology
  • Estradiol / therapeutic use*
  • Estrogens / metabolism*
  • Estrogens / therapeutic use
  • Evidence-Based Medicine
  • Female
  • Heart / drug effects
  • Humans
  • Lung / drug effects
  • Male
  • Reperfusion Injury / metabolism
  • Reperfusion Injury / mortality*
  • Sepsis / metabolism
  • Sepsis / mortality*
  • Sex Characteristics*

Substances

  • Estrogens
  • Estradiol