The role of mTOR signaling in controlling mammalian life span: what a fungicide teaches us about longevity

J Gerontol A Biol Sci Med Sci. 2010 Jun;65(6):580-9. doi: 10.1093/gerona/glp212. Epub 2010 Jan 18.
No abstract available

MeSH terms

  • Aging / metabolism
  • Aging / physiology
  • Animals
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / pharmacology*
  • Cell Proliferation
  • Disease / etiology
  • Drug Administration Schedule
  • Geriatrics / methods
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / pharmacology*
  • Intracellular Signaling Peptides and Proteins / antagonists & inhibitors*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Longevity / drug effects*
  • Longevity / physiology*
  • Metabolic Diseases / etiology
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Primary Prevention / methods
  • Protein Serine-Threonine Kinases / antagonists & inhibitors*
  • Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction / physiology*
  • Sirolimus / administration & dosage
  • Sirolimus / pharmacology*
  • TOR Serine-Threonine Kinases

Substances

  • Antifungal Agents
  • Immunosuppressive Agents
  • Intracellular Signaling Peptides and Proteins
  • MTOR protein, human
  • Protein Serine-Threonine Kinases
  • TOR Serine-Threonine Kinases
  • Sirolimus