Abstract
Bioassay-guided separation of an extract of the wings from a Taiwan butterfly, Byasa polyeuctes termessa, allowed isolation of a new cancer cell growth inhibitor designated papilistatin (1a). The structure was determined by analysis of 1D and 2D NMR spectra and by HRMS. Against a panel of six human and the murine P388 leukemia cancer cell lines, papilistatin exhibited cancer cell growth inhibition with GI(50)'s of 0.093-3.5 microg/mL. Papilistatin was also found to have antibacterial activity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Butterflies / chemistry
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Butterflies / metabolism*
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Dioxoles / chemistry
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Dioxoles / isolation & purification*
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Dioxoles / pharmacology*
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Drug Screening Assays, Antitumor
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Enterococcus faecalis / drug effects
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Humans
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Inhibitory Concentration 50
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Leukemia P388
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Microbial Sensitivity Tests
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Micrococcus luteus / drug effects
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Molecular Structure
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Phenanthrenes / chemistry
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Phenanthrenes / isolation & purification*
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Phenanthrenes / pharmacology*
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Staphylococcus aureus / drug effects
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Streptococcus pneumoniae / drug effects
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Dioxoles
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Phenanthrenes
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papilistatin