Abstract
We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC(pleural fluid)) to that in serum (AUC(serum)) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 microg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.
Publication types
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Case Reports
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Research Support, N.I.H., Intramural
MeSH terms
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Amphotericin B / administration & dosage
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Amphotericin B / blood
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Amphotericin B / pharmacokinetics*
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Antifungal Agents / administration & dosage
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Antifungal Agents / blood
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Antifungal Agents / pharmacokinetics*
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Empyema, Pleural / drug therapy
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Empyema, Pleural / metabolism
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Female
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Humans
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Liposomes
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Lung Diseases, Fungal / blood
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Lung Diseases, Fungal / drug therapy*
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Lung Diseases, Fungal / metabolism*
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Middle Aged
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Mucormycosis / blood
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Mucormycosis / drug therapy*
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Mucormycosis / metabolism*
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Pleural Effusion / drug therapy
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Pleural Effusion / metabolism*
Substances
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Antifungal Agents
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Liposomes
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liposomal amphotericin B
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Amphotericin B