Diastereo- and enantioselective anti-alkoxyallylation employing allylic gem-dicarboxylates as allyl donors via iridium-catalyzed transfer hydrogenation

J Am Chem Soc. 2010 Feb 17;132(6):1760-1. doi: 10.1021/ja9097675.

Abstract

Enantioselective transfer hydrogenation of gem-dibenzoate 1e in the presence of aromatic, alpha,beta-unsaturated, or aliphatic aldehydes 2a-i mediated by isopropyl alcohol and employing a cyclometalated iridium C,O-benzoate derived from allyl acetate, 4-cyano-3-nitrobenzoic acid, and (R)-SEGPHOS delivers products of alkoxyallylation 3a-i, 4a, 4e, 4f, and 4i in good isolated yields (62-82%) with good to excellent diastereoselectivities (7:1 to 18:1 dr) and exceptional enantioselectivities (90-99% ee). This protocol provides an alternative to the use of premetalated nucleophiles in carbonyl alkoxyallylation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / chemistry
  • Aldehydes / chemistry
  • Alkenes / chemistry*
  • Benzoic Acid / chemistry
  • Carboxylic Acids / chemistry*
  • Catalysis
  • Hydrogenation
  • Iridium / chemistry*
  • Oxidation-Reduction
  • Phosphines / chemistry
  • Stereoisomerism
  • Substrate Specificity

Substances

  • Acetates
  • Aldehydes
  • Alkenes
  • Carboxylic Acids
  • Phosphines
  • Iridium
  • Benzoic Acid
  • phosphine