Trials, travails and triumphs: an account of RNA catalysis in RNase P

William H McClain; Lien B Lai; Venkat Gopalan

doi:10.1016/j.jmb.2010.01.038

Trials, travails and triumphs: an account of RNA catalysis in RNase P

J Mol Biol. 2010 Apr 2;397(3):627-46. doi: 10.1016/j.jmb.2010.01.038. Epub 2010 Jan 25.

Authors

William H McClain¹, Lien B Lai, Venkat Gopalan

Affiliation

¹ Department of Bacteriology, College of Agriculture & Life Sciences, University of Wisconsin, Madison, WI 53706, USA. [email protected]

PMID: 20100492
DOI: 10.1016/j.jmb.2010.01.038

Abstract

Last December marked the 20th anniversary of the Nobel Prize in Chemistry to Sidney Altman and Thomas Cech for their discovery of RNA catalysts in bacterial ribonuclease P (an enzyme catalyzing 5' maturation of tRNAs) and a self-splicing rRNA of Tetrahymena, respectively. Coinciding with the publication of a treatise on RNase P, this review provides a historical narrative, a brief report on our current knowledge, and a discussion of some research prospects on RNase P.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Catalysis
Humans
RNA / chemistry*
Ribonuclease P / chemistry*

Substances

RNA
Ribonuclease P

Abstract

Publication types

MeSH terms

Substances

Grants and funding