Abstract
This study compared the activity of finafloxacin, a novel fluoroquinolone which shows enhanced activity under acidic pH, and that of ciprofloxacin against Acinetobacter baumannii under standard conditions (pH 7.2) and at a pH of 5.8. Overall, finafloxacin demonstrated superior activity to ciprofloxacin under acidic conditions. Furthermore, finafloxacin showed comparable activity to ciprofloxacin at pH 7.2. Hence, finafloxacin could be a promising new antimicrobial agent for the treatment of A. baumannii infections at acidic body compartments.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / drug therapy
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Acinetobacter Infections / microbiology
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / enzymology
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Acinetobacter baumannii / genetics
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Acinetobacter baumannii / isolation & purification
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Amino Acid Substitution
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Anti-Bacterial Agents / pharmacology*
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Ciprofloxacin / pharmacology*
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DNA Gyrase / genetics
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DNA Topoisomerase IV / genetics
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Drug Resistance, Bacterial / genetics
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Drug Resistance, Multiple, Bacterial / genetics
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Fluoroquinolones / pharmacology*
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Genes, Bacterial
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Humans
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Hydrogen-Ion Concentration
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In Vitro Techniques
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Microbial Sensitivity Tests
Substances
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Anti-Bacterial Agents
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Fluoroquinolones
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Ciprofloxacin
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finafloxacin
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DNA Topoisomerase IV
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DNA Gyrase