Blumeaenes A-J, sesquiterpenoid esters from Blumea balsamifera with NO inhibitory activity

Planta Med. 2010 Jun;76(9):897-902. doi: 10.1055/s-0029-1240800. Epub 2010 Jan 25.

Abstract

Chemical examination of the ethanol extract of the aerial parts of Blumea balsamifera led to the isolation of ten new sesquiterpenoid esters, blumeaenes A-J (1- 10), with 13 known flavonoids. Their structures were determined mainly by use of 1D and 2D NMR spectroscopic techniques. All sesquiterpenoid esters were tested for their inhibitory activity against LPS-induced NO production in RAW264.7 macrophages. Compounds 1, 4 and 5 showed slight inhibitory effect on the production of NO with IC(50) values of 40.06, 46.35 and 57.80 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Asteraceae / chemistry*
  • Cell Line
  • Lipopolysaccharides
  • Macrophages / drug effects
  • Mice
  • Molecular Structure
  • Nitric Oxide / antagonists & inhibitors*
  • Nitric Oxide / biosynthesis
  • Plant Components, Aerial
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*

Substances

  • Lipopolysaccharides
  • Plant Extracts
  • Sesquiterpenes
  • Nitric Oxide