Abstract
Two new dammarane-type glycosides, 2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-[beta-d-glucopyranosyl(1-->4)-beta-d-glucopyranosyl]-20-O-[beta-d-xylopyranosyl-(1-->6)-beta-d-glucopyranoside] (1) and 2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-beta-d-glucopyranosyl-20-O-[beta-d-6-O-acetylglucopyranosyl-(1-->2)-beta-d-glucopyranoside] (2), were isolated from a MeOH extract of the leaves of Gynostemma pentaphyllum. Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The isolated compounds showed potential inhibitory effects on eotaxin expression in BEAS-2B bronchial epithelial cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bronchi / cytology
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Bronchi / drug effects
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Dammaranes
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Epithelial Cells / drug effects
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology*
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Gynostemma / chemistry*
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Stereoisomerism
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
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Vietnam
Substances
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2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-(beta-D-glucopyranosyl(1-4)-beta-D-glucopyranosyl)-20-O-(beta-D-xylopyranosyl-(1-6)-beta-D-glucopyranoside)
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2alpha,3beta,12beta,20S-tetrahydroxydammar-24-ene-3-O-beta-D-glucopyranosyl-20-O-(beta-D-6-O-acetylglucopyranosyl-(1-2)-beta-D-glucopyranoside)
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Glucosides
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Glycosides
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Triterpenes