Rh(2)(OAc)(4)-AgOTf cooperative catalysis in cyclization/three-component reactions for concise synthesis of 1,2-dihydroisoquinolines

Org Lett. 2010 Feb 19;12(4):652-5. doi: 10.1021/ol902409u.

Abstract

Dirhodium acetate and silver triflate cooperatively catalyzed tandem cyclization/three-component reactions of 2-alkynylarylaldimines with diazo compounds and water or alcohols are reported to afford 1,2-dihydroisoquinolines bearing alpha-hydroxyl-beta-amino carboxylate skeleton in high yield.