Abstract
Lichen sclerosus is a chronic inflammatory mucocutaneous disease that is highly bothersome for men and women of all ages. The exact etiology is unknown, although genetic and autoimmune factors, as well as infections, have been implicated in its pathogenesis. First-line treatment is highly potent topical corticosteroid therapy for short periods. Surgery is reserved for cases of phimosis, urethral stenosis, synechiae, and squamous cell carcinoma.
MeSH terms
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Adrenal Cortex Hormones / therapeutic use
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Adult
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Algorithms
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Anti-Inflammatory Agents / therapeutic use
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Autoimmune Diseases / immunology
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Child
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Diagnosis, Differential
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Female
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Genetic Predisposition to Disease
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Genital Diseases, Female / diagnosis
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Genital Diseases, Female / pathology
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Genital Diseases, Male / diagnosis
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Genital Diseases, Male / pathology
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Gonadal Steroid Hormones / physiology
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Humans
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Lichen Sclerosus et Atrophicus* / diagnosis
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Lichen Sclerosus et Atrophicus* / drug therapy
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Lichen Sclerosus et Atrophicus* / etiology
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Lichen Sclerosus et Atrophicus* / pathology
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Lichen Sclerosus et Atrophicus* / physiopathology
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Lichen Sclerosus et Atrophicus* / surgery
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Male
Substances
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Adrenal Cortex Hormones
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Anti-Inflammatory Agents
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Gonadal Steroid Hormones