Debugging the intestinal microbiota in IBD

R Dessein; P Rosenstiel; M Chamaillard

doi:10.1016/S0399-8320(09)73148-3

Debugging the intestinal microbiota in IBD

Gastroenterol Clin Biol. 2009 Jun:33 Suppl 3:S131-6. doi: 10.1016/S0399-8320(09)73148-3.

Authors

R Dessein¹, P Rosenstiel, M Chamaillard

Affiliation

¹ INSERM U801, Lille, F-59019 France; University of Lille 2, Lille, F-59000, France.

PMID: 20117336
DOI: 10.1016/S0399-8320(09)73148-3

Abstract

Besides its role in repelling enteropathogenic infections, the gastrointestinal tract is in intimate contact with commensal microbiota. Tremendous advances have been made in determining the pivotal role of the microbiota in both tissue homeostasis and metabolism, as well as in the initiation and maintenance of inflammatory lesions in inflammatory bowel diseases. A better understanding of human gut microbiota could provide innovative targets for treating and/or curing such common immunopathologies of the gastrointestinal tract.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacteria / metabolism*
Gastrointestinal Tract / immunology
Gastrointestinal Tract / microbiology*
Humans
Inflammatory Bowel Diseases / immunology
Inflammatory Bowel Diseases / metabolism
Inflammatory Bowel Diseases / microbiology*
Inflammatory Bowel Diseases / therapy
Metagenome*
Probiotics / therapeutic use