Increased levels of oxidants and reduced antioxidants in semen of infertile men with varicocele

Mohamed Ahmed Abd-Elmoaty; Ramadan Saleh; Rakesh Sharma; Ashok Agarwal

doi:10.1016/j.fertnstert.2009.12.039

Increased levels of oxidants and reduced antioxidants in semen of infertile men with varicocele

Fertil Steril. 2010 Sep;94(4):1531-1534. doi: 10.1016/j.fertnstert.2009.12.039. Epub 2010 Feb 1.

Authors

Mohamed Ahmed Abd-Elmoaty¹, Ramadan Saleh², Rakesh Sharma³, Ashok Agarwal⁴

Affiliations

¹ Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag, Egypt.
² Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.
³ Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio.
⁴ Center for Reproductive Medicine, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address: [email protected].

PMID: 20117772
DOI: 10.1016/j.fertnstert.2009.12.039

Abstract

Significantly higher levels of oxidants (malonaldehyde and nitric oxide) and reduced levels of antioxidants (superoxide dismutase, glutathione peroxidase, catalase, and ascorbic acid) are seen in semen of infertile men with varicocele. Seminal oxidative stress (OS) seen in men with varicocele is associated with sperm motility and grade of varicocele.

MeSH terms

Antioxidants / metabolism*
Ascorbic Acid / metabolism
Case-Control Studies
Catalase / metabolism
Glutathione Peroxidase / metabolism
Humans
Infertility, Male / etiology
Infertility, Male / metabolism*
Male
Malondialdehyde / metabolism
Nitric Oxide / metabolism
Oxidants / metabolism*
Semen / metabolism*
Semen Analysis
Superoxide Dismutase / metabolism
Up-Regulation
Varicocele / complications
Varicocele / metabolism*

Substances

Antioxidants
Oxidants
Nitric Oxide
Malondialdehyde
Catalase
Glutathione Peroxidase
Superoxide Dismutase
Ascorbic Acid