Abstract
Two different strategies, namely a dialdehyde-based cross-linking and photo-affinity labeling, have been developed to generate small molecule activity-based probes (ABPs) for the Abelson (Abl) tyrosine kinase, of which probe 13, derived from the photo-affinity approach, showed specific labeling of Abl kinase present in a crude mammalian proteome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Amino Acid Sequence
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Catalytic Domain
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Fluorescent Dyes / chemistry
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Proto-Oncogene Proteins c-abl / chemistry*
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Proto-Oncogene Proteins c-abl / genetics
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Proto-Oncogene Proteins c-abl / metabolism
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Recombinant Proteins / chemistry
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Recombinant Proteins / genetics
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Recombinant Proteins / metabolism
Substances
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Aldehydes
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Fluorescent Dyes
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Pyridines
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Recombinant Proteins
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Proto-Oncogene Proteins c-abl