SUMO boosts the DNA damage response barrier against cancer

Jiri Bartek; Zdenek Hodny

doi:10.1016/j.ccr.2009.12.030

SUMO boosts the DNA damage response barrier against cancer

Cancer Cell. 2010 Jan 19;17(1):9-11. doi: 10.1016/j.ccr.2009.12.030.

Authors

Jiri Bartek¹, Zdenek Hodny

Affiliation

¹ Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. [email protected]

PMID: 20129245
DOI: 10.1016/j.ccr.2009.12.030

Abstract

Cells exposed to genotoxic insults such as ionizing radiation activate a signaling cascade to repair the damaged DNA. Two recent articles published in Nature show that such genome maintenance requires modifications of tumor suppressor proteins BRCA1 and 53BP1 by the small ubiquitin-like modifier SUMO.

Publication types

Review

MeSH terms

Animals
BRCA1 Protein / metabolism
DNA Damage / physiology*
DNA Repair / physiology*
Humans
Intracellular Signaling Peptides and Proteins / metabolism
Neoplasms / genetics*
Neoplasms / metabolism*
SUMO-1 Protein / metabolism*
Signal Transduction / physiology
Tumor Suppressor p53-Binding Protein 1

Substances

BRCA1 Protein
Intracellular Signaling Peptides and Proteins
SUMO-1 Protein
TP53BP1 protein, human
Tumor Suppressor p53-Binding Protein 1