The evolution of protease mutation 76V is associated with protease mutation 46I and gag mutation 431V

Elena Knops; Ina Kemper; Eugen Schülter; Herbert Pfister; Rolf Kaiser; Jens Verheyen

doi:10.1097/QAD.0b013e328336784d

The evolution of protease mutation 76V is associated with protease mutation 46I and gag mutation 431V

AIDS. 2010 Mar 13;24(5):779-81. doi: 10.1097/QAD.0b013e328336784d.

Authors

Elena Knops¹, Ina Kemper, Eugen Schülter, Herbert Pfister, Rolf Kaiser, Jens Verheyen

Affiliation

¹ University of Cologne, Institute of Virology, Cologne, Germany.

PMID: 20139751
DOI: 10.1097/QAD.0b013e328336784d

Abstract

Recently, first-line lopinavir failure was observed due to protease mutation 76V. In the present study, we found 76V associated with protease mutation 46I and gag cleavage-site mutation 431V. Longitudinal analysis of patients failing protease inhibitor therapies demonstrated that 76V strictly occurs either together with 46I and/or 431V or in HIV isolates already harbouring one of both mutations. Therefore, all three mutations seem to cooperate in terms of protease inhibitor resistance.

MeSH terms

Drug Resistance, Viral / genetics*
Evolution, Molecular
Female
HIV Infections / drug therapy
HIV Infections / genetics*
HIV Protease Inhibitors / therapeutic use
HIV-1 / genetics*
Humans
Lopinavir
Male
Molecular Sequence Data
Mutation
Pyrimidinones / therapeutic use
Sequence Analysis, DNA
gag Gene Products, Human Immunodeficiency Virus / genetics*
pol Gene Products, Human Immunodeficiency Virus / genetics*

Substances

HIV Protease Inhibitors
Pyrimidinones
gag Gene Products, Human Immunodeficiency Virus
pol Gene Products, Human Immunodeficiency Virus
Lopinavir