The role of nucleotide sugar transporters in development of eukaryotes

Semin Cell Dev Biol. 2010 Aug;21(6):600-8. doi: 10.1016/j.semcdb.2010.02.002. Epub 2010 Feb 6.

Abstract

The Golgi apparatus membrane of all eukaryotes has nucleotide sugar transporters which play essential roles in the glycosylation of glycoproteins, proteoglycans and glycolipids. Mutations of these transporters have broad developmental phenotypes across many species including diseases in humans and cattle.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Carbohydrate Metabolism*
  • Eukaryota / cytology
  • Eukaryota / physiology*
  • Golgi Apparatus / metabolism*
  • Humans
  • Leishmania / metabolism
  • Leishmania / pathogenicity
  • Membrane Transport Proteins / genetics
  • Membrane Transport Proteins / metabolism*
  • Molecular Sequence Data
  • Mutation
  • Nucleotides / metabolism*
  • Phenotype
  • Sequence Alignment

Substances

  • Membrane Transport Proteins
  • Nucleotides