Small molecule JNK (c-Jun N-terminal kinase) inhibitors

J Med Chem. 2010 Apr 22;53(8):3005-12. doi: 10.1021/jm9003279.

Authors

M Arshad Siddiqui¹, Panduranga A Reddy

Affiliation

¹ Merck Research Laboratories, 320 Bent Street, Cambridge, Massachusetts 02141, USA. [email protected]

PMID: 20146479
DOI: 10.1021/jm9003279

No abstract available

MeSH terms

Allosteric Regulation
Animals
Cardiovascular Diseases / enzymology
Crystallography, X-Ray
Humans
Inflammation / enzymology
Inflammation / immunology
Isoenzymes / antagonists & inhibitors
Isoenzymes / chemistry
JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors*
JNK Mitogen-Activated Protein Kinases / chemistry
JNK Mitogen-Activated Protein Kinases / physiology
Metabolic Diseases / enzymology
Neurodegenerative Diseases / enzymology
Protein Conformation
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology*
Signal Transduction

Substances

Isoenzymes
Protein Kinase Inhibitors
JNK Mitogen-Activated Protein Kinases