Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes

Daisuke Oikawa; Ryoko Akai; Takao Iwawaki

doi:10.1016/j.febslet.2010.02.012

Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes

FEBS Lett. 2010 Mar 5;584(5):1066-70. doi: 10.1016/j.febslet.2010.02.012. Epub 2010 Feb 9.

Authors

Daisuke Oikawa¹, Ryoko Akai, Takao Iwawaki

Affiliation

¹ Iwawaki Initiative Research Unit, Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

PMID: 20146926
DOI: 10.1016/j.febslet.2010.02.012

Abstract

Inositol requiring enzyme-1alpha (IRE1alpha) is an ER-located transmembrane RNase whose activation leads to the production of the transcription factor X-box binding protein 1 (XBP1). Recently, we showed that the IRE1alpha-XBP1 pathway plays an essential role in the placenta. However, details of its function remain unclear. To address this point, we searched for IRE1alpha- or XBP1-regulated genes in the placenta, and identified the CEA family as a novel target of the IRE1alpha-XBP1 pathway. Moreover, PSG genes, which also belong to the CEA family, were up-regulated by XBP1. We have therefore identified a new aspect of the physiological function of the IRE1alpha-XBP1 pathway in the placenta.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carcinoembryonic Antigen / genetics
Carcinoembryonic Antigen / metabolism*
Cell Adhesion Molecules / genetics
Cell Adhesion Molecules / metabolism
Cell Line
Chromatin Immunoprecipitation
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Endoribonucleases / genetics
Endoribonucleases / metabolism*
Female
Gene Expression Regulation*
Mice
Mice, Knockout
Placenta / metabolism*
Pregnancy
Pregnancy Proteins / genetics
Pregnancy Proteins / metabolism
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism*
Regulatory Factor X Transcription Factors
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction / genetics
Signal Transduction / physiology
Transcription Factors / genetics
Transcription Factors / metabolism*
X-Box Binding Protein 1

Substances

Carcinoembryonic Antigen
Cell Adhesion Molecules
DNA-Binding Proteins
Pregnancy Proteins
Regulatory Factor X Transcription Factors
Transcription Factors
X-Box Binding Protein 1
Xbp1 protein, mouse
Ern1 protein, mouse
Protein Serine-Threonine Kinases
Endoribonucleases