Abstract
This study investigated whether the GnRH antagonist ganirelix is able to block the positive-feedback effect of E2 in normal women. Ganirelix was unable to block the positive-feedback effect, suggesting that the clinical efficacy of GnRH antagonists in IVF cycles is determined by the hyperstimulation process.
Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Publication types
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Controlled Clinical Trial
MeSH terms
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Administration, Cutaneous
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Adult
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Estradiol / administration & dosage
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Estradiol / blood
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Estradiol / pharmacology*
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Feedback, Physiological / drug effects*
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Female
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Gonadotropin-Releasing Hormone / administration & dosage
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Gonadotropin-Releasing Hormone / analogs & derivatives*
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Gonadotropin-Releasing Hormone / antagonists & inhibitors*
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Gonadotropin-Releasing Hormone / pharmacology
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Gonadotropin-Releasing Hormone / therapeutic use
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Health
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Hormone Antagonists / administration & dosage
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Hormone Antagonists / pharmacology
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Hormone Antagonists / therapeutic use
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Humans
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Menstrual Cycle / blood
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Menstrual Cycle / drug effects
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Ovulation Induction
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Progesterone / blood
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Treatment Failure
Substances
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Hormone Antagonists
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Gonadotropin-Releasing Hormone
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Progesterone
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Estradiol
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ganirelix