Locomotion analysis of Sprague-Dawley rats before and after injecting 6-OHDA

Behav Brain Res. 2010 Jun 26;210(1):131-3. doi: 10.1016/j.bbr.2010.02.012. Epub 2010 Feb 12.

Abstract

The hypothesis that changes in measured ground reaction forces and time parameters during locomotion can noninvasively detect Parkinsonism in unilateral 6-OH dopamine (6-OHDA) lesioned rats is tested. It was found that changes of seven locomotion parameters can be used to construct a logistic regression model with a detection sensitivity and specificity of over 90% as compared to non-lesioned rats. Comparisons between this model and other neurological and neuromuscular disorders are presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyotrophic Lateral Sclerosis / diagnosis
  • Animals
  • Biomechanical Phenomena
  • Disease Models, Animal
  • Locomotion*
  • Logistic Models
  • Muscle, Skeletal / injuries
  • Oxidopamine
  • Parkinsonian Disorders / chemically induced
  • Parkinsonian Disorders / diagnosis*
  • Probability
  • Rats
  • Rats, Sprague-Dawley
  • Reaction Time
  • Sensitivity and Specificity
  • Time Factors

Substances

  • Oxidopamine