Malignant blue nevus

Cancer. 1991 May 15;67(10):2653-7. doi: 10.1002/1097-0142(19910515)67:10<2653::aid-cncr2820671041>3.0.co;2-u.

Abstract

To elucidate the histologic features and biologic behavior of malignant blue nevus (MBN), 12 cases were analyzed in which the tumor showed no junctional activity and arose in a blue nevus background. Seven patients were men and five were women; their mean age was 48.8 years. Eight lesions were on the scalp, and no patient had a family history of melanoma. The histologic appearance of most lesions was a nodule or nodules of malignant cells in a blue nevus. Mitoses were present in all lesions with atypical forms in eight; however the mitotic rate exceeded two per ten high-power fields in only one lesion. Four lesions had necrosis, and four had a heavily pigmented malignant component. Four patients had recurrences; ten patients had metastases, and eight died of their disease. Therefore MBN is an aggressive neoplasm.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Liver Neoplasms / secondary
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Mitosis
  • Necrosis
  • Nevus, Pigmented / metabolism
  • Nevus, Pigmented / pathology*
  • Nevus, Pigmented / secondary
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology*