Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China

AIDS Res Hum Retroviruses. 2010 Feb;26(2):217-21. doi: 10.1089/aid.2009.0157.

Abstract

Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.9%). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6% vs. 0%, 45.5% vs. 12.5%, p < 0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • China
  • Cluster Analysis
  • Drug Resistance, Viral*
  • Female
  • Geography
  • HIV Infections / virology*
  • HIV-1 / drug effects*
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification
  • Humans
  • Korea
  • Male
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Mutation, Missense*
  • Phylogeny
  • Polymorphism, Genetic
  • Sequence Analysis, DNA
  • Viral Proteins / genetics*
  • Young Adult

Substances

  • Viral Proteins

Associated data

  • GENBANK/GQ290693
  • GENBANK/GQ290694
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