Amplification of epidermal growth factor receptor gene in renal cell carcinoma

Iman El-Hariry; Thomas Powles; Mike R Lau; Cora N Sternberg; Alain Ravaud; Hans von der Maase; Niko Zantl; Peter Harper; Frédéric Rolland; Bruno Audhuy; Friederike Barthel; Jean-Pascal Machiels; Pina Patel; Ernst-Dietrick Kreuser; Robert E Hawkins

doi:10.1016/j.ejca.2010.01.011

Amplification of epidermal growth factor receptor gene in renal cell carcinoma

Eur J Cancer. 2010 Mar;46(5):859-62. doi: 10.1016/j.ejca.2010.01.011. Epub 2010 Feb 16.

Authors

Iman El-Hariry¹, Thomas Powles, Mike R Lau, Cora N Sternberg, Alain Ravaud, Hans von der Maase, Niko Zantl, Peter Harper, Frédéric Rolland, Bruno Audhuy, Friederike Barthel, Jean-Pascal Machiels, Pina Patel, Ernst-Dietrick Kreuser, Robert E Hawkins

Affiliation

¹ Oncology Business Unit, GlaxoSmithKline, London UB11 1BT, United Kingdom.

PMID: 20167476
DOI: 10.1016/j.ejca.2010.01.011

Abstract

Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.

Publication types

Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell / genetics*
Carcinoma, Renal Cell / metabolism
ErbB Receptors / biosynthesis*
ErbB Receptors / genetics
Female
Gene Amplification*
Gene Expression Regulation, Neoplastic*
Humans
In Situ Hybridization, Fluorescence
Kidney Neoplasms / genetics*
Kidney Neoplasms / metabolism
Male
Middle Aged
Prognosis
Prospective Studies
Survival Analysis

Substances

ErbB Receptors