Abstract
The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that activates caspase 1, leading to the processing and secretion of the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and IL-18. The NLRP3 inflammasome is activated by a wide range of danger signals that derive not only from microorganisms but also from metabolic dysregulation. It is unclear how these highly varied stress signals can be detected by a single inflammasome. In this Opinion article, we review the different signalling pathways that have been proposed to engage the NLRP3 inflammasome and suggest a model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS).
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology
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Antigen-Antibody Complex / immunology
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Antigen-Antibody Complex / metabolism
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Carrier Proteins / immunology
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Carrier Proteins / metabolism*
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Humans
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Inflammation / drug therapy
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Inflammation / immunology
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Inflammation / metabolism*
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Interleukin-1 / antagonists & inhibitors
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Interleukin-1 / immunology
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Mice
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Mice, Knockout
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NLR Family, Pyrin Domain-Containing 3 Protein
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Reactive Oxygen Species / immunology
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Reactive Oxygen Species / metabolism*
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Signal Transduction
Substances
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Anti-Inflammatory Agents
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Antigen-Antibody Complex
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Carrier Proteins
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Interleukin-1
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NLR Family, Pyrin Domain-Containing 3 Protein
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Nlrp3 protein, mouse
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Reactive Oxygen Species