Abstract
We previously reported increased binding of (+)[11C]DTBZ (dihydrotetrabenazine), the vesicular monoamine transporter (VMAT2) positron emission tomography (PET) radioligand, in striatum of some methamphetamine users. This finding might be explained by stimulant-induced vesicular DA depletion resulting in decreased DA (+)[11C]DTBZ competition at VMAT2. In a prospective PET study, we now find that administration of an acute oral dose of amphetamine (0.4 mg/kg) to humans does not cause increased striatal (+)[11C]DTBZ binding but a slight 5% decrease. Our data suggest that a low amphetamine dose is unlikely to cause sufficient DA depletion to detect increased (+)[11C]DTBZ binding and that a higher dose might be required.
MeSH terms
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Administration, Oral
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Adult
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Amphetamine / pharmacology*
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Amphetamine-Related Disorders / metabolism
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Amphetamine-Related Disorders / physiopathology
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Binding, Competitive / drug effects
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Binding, Competitive / physiology
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Central Nervous System Stimulants / pharmacology
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Corpus Striatum / diagnostic imaging
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Corpus Striatum / drug effects*
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Corpus Striatum / metabolism
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Dopamine / metabolism
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Dose-Response Relationship, Drug
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Female
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Humans
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Male
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Positron-Emission Tomography / methods*
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Prospective Studies
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Tetrabenazine / analogs & derivatives*
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Tetrabenazine / metabolism
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Vesicular Monoamine Transport Proteins / drug effects*
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Vesicular Monoamine Transport Proteins / metabolism
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Young Adult
Substances
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Central Nervous System Stimulants
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SLC18A2 protein, human
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Vesicular Monoamine Transport Proteins
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dihydrotetrabenazine
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Amphetamine
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Dopamine
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Tetrabenazine