Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway

Maria Vittoria Spanedda; Béatrice Heurtault; Steffen Weidner; Corinne Baehr; Emmanuelle Boeglin; Julien Beyrath; Sara Milosevic; Line Bourel-Bonnet; Sylvie Fournel; Benoît Frisch

doi:10.1016/j.bmcl.2010.01.146

Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1869-72. doi: 10.1016/j.bmcl.2010.01.146. Epub 2010 Feb 2.

Authors

Maria Vittoria Spanedda¹, Béatrice Heurtault, Steffen Weidner, Corinne Baehr, Emmanuelle Boeglin, Julien Beyrath, Sara Milosevic, Line Bourel-Bonnet, Sylvie Fournel, Benoît Frisch

Affiliation

¹ Equipe de Biovectorologie, Laboratoire de Conception et Application des Molécules Bioactives, UMR 7199 CNRS/Université de Strasbourg, Faculté de Pharmacie, Illkirch Cedex, France.

PMID: 20172719
DOI: 10.1016/j.bmcl.2010.01.146

Abstract

Four novel water-soluble lipid immunoadjuvants were designed, synthesized and characterized by MS and NMR. They all induce mouse dendritic cell maturation and B cell proliferation. We demonstrate that in spite of the chemical modification, the four compounds remain TLR2 agonists.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic / pharmacology*
Animals
B-Lymphocytes / cytology*
Cell Proliferation / drug effects*
Dendritic Cells / cytology*
Lipids / pharmacology*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mice
Solubility
Toll-Like Receptor 2 / metabolism*
Water

Substances

Adjuvants, Immunologic
Lipids
Tlr2 protein, mouse
Toll-Like Receptor 2
Water