Abstract
We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after lesion and was lost on differentiation into oligodendrocytes. Therefore, axon-oligodendrocyte progenitor synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult Stem Cells / physiology*
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Animals
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Axons / physiology
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Cell Differentiation
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Cell Movement
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Corpus Callosum / injuries
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Corpus Callosum / physiopathology*
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Excitatory Postsynaptic Potentials
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Glutamic Acid / metabolism
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In Vitro Techniques
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Membrane Potentials / physiology
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Myelin Sheath / physiology*
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NIH 3T3 Cells
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Neurons / physiology
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Oligodendroglia / physiology*
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Stem Cell Niche / physiology*
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Synapses / physiology*
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Synaptic Transmission / physiology