Abstract
The myosin tail domain interacting protein-myosin A (MTIP-MyoA) protein complex is an essential element of the motor driving invasion of red blood cells by the Plasmodium species that cause malaria. Here we report the key determinants of binding at the MTIP/MyoA interface, and the first structural study on the complex in solution using protein NMR.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Cytoskeletal Proteins / chemistry
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Cytoskeletal Proteins / metabolism*
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Host-Parasite Interactions / physiology
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Membrane Proteins / chemistry
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Membrane Proteins / metabolism*
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Molecular Sequence Data
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Multiprotein Complexes / chemistry
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Multiprotein Complexes / metabolism
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Myosins / chemistry
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Myosins / metabolism*
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Nuclear Magnetic Resonance, Biomolecular
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Plasmodium falciparum / physiology*
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Protozoan Proteins / chemistry
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Protozoan Proteins / metabolism*
Substances
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Cytoskeletal Proteins
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Membrane Proteins
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Multiprotein Complexes
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Protozoan Proteins
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Myosins