Foamy cell angiosarcoma: a rare and deceptively bland variant of cutaneous angiosarcoma

J Cutan Pathol. 2010 Aug;37(8):901-6. doi: 10.1111/j.1600-0560.2010.01512.x. Epub 2010 Feb 8.

Abstract

Cutaneous angiosarcoma can sometimes mimic other benign and malignant lesions, thereby presenting a difficult differential diagnosis. In the two cases of cutaneous angiosarcoma presented herein, extensive foamy cell alteration of tumor cells resembled a reactive xanthogranulomatous process. Foamy cell angiosarcoma is an unusual and deceptively benign morphologic variant of cutaneous angiosarcoma. Critical features for diagnosis include the presence of a deep, permeative, sometimes 'scaffolding' growth pattern and subtle areas of vascular formation.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Diagnosis, Differential
  • Foam Cells / pathology*
  • Forehead / pathology
  • Granuloma / pathology*
  • Head and Neck Neoplasms / pathology*
  • Hemangiosarcoma / pathology*
  • Humans
  • Male
  • Shoulder / pathology
  • Skin Neoplasms / pathology*
  • Xanthomatosis / pathology*
  • Young Adult