Abstract
A new cytotoxic triterpenoid, schinalactone A (1), together with two new biogenetically related compounds, schinalactones B (2) and C (3), has been isolated from the roots and stems of Schisandra sphenanthera.Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant cytotoxicity against PANC-1 cell lines with IC(50) values of 5.9 and 4.1 microM, respectively. A plausible biosynthetic pathway of 1 was also postulated.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Cell Line, Tumor
-
Cell Proliferation / drug effects
-
Drug Screening Assays, Antitumor
-
HL-60 Cells
-
Humans
-
Molecular Conformation
-
Plant Roots / chemistry
-
Plant Stems / chemistry
-
Schisandra / chemistry*
-
Stereoisomerism
-
Structure-Activity Relationship
-
Triterpenes / chemistry
-
Triterpenes / isolation & purification
-
Triterpenes / pharmacology*
Substances
-
Antineoplastic Agents, Phytogenic
-
Triterpenes
-
schinalactone A
-
schinalactone B
-
schinalactone C