The effects of healthy aging on cerebral hemodynamic responses to posture change

Physiol Meas. 2010 Apr;31(4):477-95. doi: 10.1088/0967-3334/31/4/002. Epub 2010 Feb 24.

Abstract

Aging is associated with an increased incidence of orthostatic hypotension, impairment of the baroreceptor reflex and lower baseline cerebral blood flow. The effect of aging on cerebrovascular autoregulation, however, remains to be fully elucidated. We used a novel optical instrument to assess microvascular cerebral hemodynamics in the frontal lobe cortex of 60 healthy subjects ranging from ages 20-78. Diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) were used to measure relative cerebral blood flow (rCBF), total hemoglobin concentration (THC), oxyhemoglobin concentration (HbO(2)) and deoxyhemoglobin concentration (Hb). Cerebral hemodynamics were monitored for 5 min at each of the following postures: head-of-bed 30 degrees , supine, standing and supine. Supine-to-standing posture change caused significant declines in rCBF, THC and HbO(2), and an increase in Hb, across the age continuum (p < 0.01). Healthy aging did not alter postural changes in frontal cortical rCBF (p = 0.23) and was associated with a smaller magnitude of decline in HbO(2) (p < 0.05) during supine-to-standing posture change. We conclude that healthy aging does not alter postural changes in frontal cortical perfusion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aging / physiology*
  • Cerebrovascular Circulation / physiology*
  • Female
  • Frontal Lobe / physiology*
  • Humans
  • Male
  • Middle Aged
  • Movement / physiology*
  • Postural Balance / physiology*
  • Posture / physiology*