Ionic liquid mediated synthesis of 5-halouracil nucleosides: key precursors for potential antiviral drugs

Nucleosides Nucleotides Nucleic Acids. 2009 Sep;28(9):821-34. doi: 10.1080/15257770903170252.

Abstract

Synthesis of antiviral 5-halouracil nucleosides, also used as key precursors for the synthesis of other potential antiviral drugs, has been demonstrated using ionic liquids as convenient and efficient reaction medium.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acetylation
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Drug Discovery
  • Halogenation*
  • Ionic Liquids / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Uridine / chemistry*

Substances

  • Antiviral Agents
  • Ionic Liquids
  • Uridine