Abstract
We report two cases of cutaneous granuloma induced by anti-TNF-alpha therapy: a 47-year-old man suffering from psoriatic arthritis treated with infliximab and a 56-year-old woman treated with adalimumab for polyarticular juvenile rheumatoid arthritis. The biospies confirmed the diagnosis of a 'sarcoidosis-like' reaction. No systemic involvement was observed. Such cases of noninfectious granulomatous diseases occurring during anti-TNF-alpha therapy are becoming increasingly frequent.
2010 S. Karger AG, Basel.
MeSH terms
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Adalimumab
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Antibodies, Monoclonal / adverse effects*
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal, Humanized
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Arthritis, Juvenile / drug therapy*
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Arthritis, Psoriatic / drug therapy*
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Etanercept
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Female
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Humans
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Immunoglobulin G / adverse effects*
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Immunoglobulin G / therapeutic use
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Infliximab
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Male
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Middle Aged
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Receptors, Tumor Necrosis Factor / therapeutic use
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Sarcoidosis / diagnosis
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Sarcoidosis / etiology*
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Sarcoidosis / pathology
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Skin Diseases / diagnosis
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Skin Diseases / etiology*
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Skin Diseases / pathology
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Immunoglobulin G
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Receptors, Tumor Necrosis Factor
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Tumor Necrosis Factor-alpha
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Infliximab
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Adalimumab
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Etanercept