Abstract
A new guaiane-type sesquiterpene glycoside, torilolone 8-O-beta-D-glucopyranoside (1), together with a known analogue compound, torilolone 11-O-beta-D-glucopyranoside (2), was isolated from the fruits of Daucus carota L. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analyses coupled with chemical degradation. The cytotoxic activities of two isolated compounds were evaluated against two human gastric cancer cell lines BGC-823 and AGS using MTT assay.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Carbohydrate Conformation
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Cell Line, Tumor
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Coloring Agents
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Daucus carota / chemistry*
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Drug Screening Assays, Antitumor
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Fruit / chemistry*
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Glucosides / pharmacology*
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Glycosides / chemistry
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Humans
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Hydrolysis
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Sesquiterpenes, Guaiane / chemistry*
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Sesquiterpenes, Guaiane / pharmacology*
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Stomach Neoplasms / drug therapy
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Tetrazolium Salts
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Thiazoles
Substances
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Antineoplastic Agents, Phytogenic
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Coloring Agents
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Glucosides
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Glycosides
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Sesquiterpenes, Guaiane
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Tetrazolium Salts
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Thiazoles
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torilolone 8-O-beta-D-glucopyranoside
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thiazolyl blue