Hyperprolactinaemia in early psychosis-not only due to antipsychotics

Jacqueline Aston; Evelyne Rechsteiner; Nadine Bull; Stefan Borgwardt; Ute Gschwandtner; Anita Riecher-Rössler

doi:10.1016/j.pnpbp.2010.02.019

Hyperprolactinaemia in early psychosis-not only due to antipsychotics

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Oct 1;34(7):1342-4. doi: 10.1016/j.pnpbp.2010.02.019. Epub 2010 Feb 24.

Authors

Jacqueline Aston¹, Evelyne Rechsteiner, Nadine Bull, Stefan Borgwardt, Ute Gschwandtner, Anita Riecher-Rössler

Affiliation

¹ Psychiatric University Outpatient Department, Psychiatric University Clinics Basel, c/o University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.

PMID: 20188136
DOI: 10.1016/j.pnpbp.2010.02.019

Abstract

Hyperprolactinaemia is often found in patients with schizophrenia and usually considered a consequence of antipsychotics. Prolactin levels were measured in 43 At-Risk Mental State individuals (ARMS) and 26 patients with First Episode Psychosis (FEP). Hyperprolactinaemia was found in 25.6% of ARMS and 46.2% of FEP. Within 60 antipsychotic-naïve ARMS and FEP, hyperprolactinaemia was found in 26.7%. Hyperprolactinaemia may be pre-existing in a subgroup of patients with schizophrenia.

MeSH terms

Adult
Antipsychotic Agents / adverse effects*
Female
Humans
Hyperprolactinemia / blood
Hyperprolactinemia / etiology*
Immunoassay / methods
Male
Mental Disorders / drug therapy
Mental Status Schedule
Prolactin / blood
Sex Factors
Young Adult

Substances

Antipsychotic Agents
Prolactin