Hyaluronic acid binding and acrosin activity are decreased in sperm from men with spinal cord injury

Viacheslav Iremashvili; Nancy L Brackett; Emad Ibrahim; Teodoro C Aballa; Darren Bruck; Charles M Lynne

doi:10.1016/j.fertnstert.2010.01.015

Hyaluronic acid binding and acrosin activity are decreased in sperm from men with spinal cord injury

Fertil Steril. 2010 Oct;94(5):1925-7. doi: 10.1016/j.fertnstert.2010.01.015. Epub 2010 Feb 26.

Authors

Viacheslav Iremashvili¹, Nancy L Brackett, Emad Ibrahim, Teodoro C Aballa, Darren Bruck, Charles M Lynne

Affiliation

¹ The Miami Project to Cure Paralysis, Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA.

PMID: 20188360
DOI: 10.1016/j.fertnstert.2010.01.015

Abstract

In this study, acrosin activity and hyaluronic acid binding were compared in sperm from men with spinal cord injury versus sperm from healthy controls. The results showed statistically significantly lower acrosin activity and statistically significantly lower hyaluronic acid binding in spinal cord injured patients compared with controls, indicating functional impairments that may diminish the capacity of the sperm to fertilize oocytes.

MeSH terms

Acrosin / metabolism*
Adult
Case-Control Studies
Humans
Hyaluronic Acid / metabolism*
Infertility, Male / metabolism
Infertility, Male / physiopathology
Male
Sperm Motility / physiology
Sperm-Ovum Interactions / physiology
Spermatozoa / metabolism*
Spinal Cord Injuries / metabolism*

Substances

Hyaluronic Acid
Acrosin