A bird's-eye view of MeCP2 binding

Mol Cell. 2010 Feb 26;37(4):451-2. doi: 10.1016/j.molcel.2010.02.006.

Abstract

In this issue of Molecular Cell, work from Skene, Bird, and colleagues reexamines MeCP2 function in the brain by characterizing the abundance and distribution of MeCP2 protein in mouse neurons and its role in regulating chromatin structure (Skene et al., 2010).

Publication types

  • Comment

MeSH terms

  • Animals
  • Brain / cytology
  • Brain / metabolism
  • Chromatin / metabolism*
  • Histones / metabolism*
  • Humans
  • Methyl-CpG-Binding Protein 2 / deficiency
  • Methyl-CpG-Binding Protein 2 / metabolism*
  • Mice
  • Neurons / cytology
  • Neurons / metabolism*
  • Protein Binding
  • Protein Multimerization

Substances

  • Chromatin
  • Histones
  • Mecp2 protein, mouse
  • Methyl-CpG-Binding Protein 2