StIKKing together: do multiple IKK pathways cooperate in the DNA-damage response?

David F Allison; Marty W Mayo

doi:10.1016/j.molcel.2010.02.004

StIKKing together: do multiple IKK pathways cooperate in the DNA-damage response?

Mol Cell. 2010 Feb 26;37(4):453-4. doi: 10.1016/j.molcel.2010.02.004.

Authors

David F Allison¹, Marty W Mayo

Affiliation

¹ Department of Biochemistry and Molecular Genetics, Box 800733, University of Virginia, Charlottesville, VA 22908, USA.

PMID: 20188663
DOI: 10.1016/j.molcel.2010.02.004

Abstract

Although IKK-related kinases are known to augment immune pathways, their importance to DNA-damage response has not been previously elucidated; in this issue of Molecular Cell, Renner et al. (2010) show that genotoxic stress requires SUMOylated IKKvarepsilon to regulate NF-kappaB transcription and cell survival.

Publication types

Comment

MeSH terms

Apoptosis*
DNA Damage*
I-kappa B Kinase / genetics
I-kappa B Kinase / metabolism*
Protein Binding
SUMO-1 Protein / metabolism
Signal Transduction*

Substances

SUMO-1 Protein
I-kappa B Kinase