Electrochemical concentration of no-carrier-added [(18)F]fluoride from [(18)O]water in a disposable microfluidic cell for radiosynthesis of (18)F-labeled radiopharmaceuticals

Appl Radiat Isot. 2010 Sep;68(9):1703-8. doi: 10.1016/j.apradiso.2010.02.005. Epub 2010 Feb 13.

Abstract

The realization of the electrochemical method for microfluidic radiosynthesis is described for concentrating aqueous no-carrier-added [(18)F]fluoride into an aprotic solvent in a disposable microfluidic cell. Flowing aqueous [(18)F]fluoride was introduced into a disposable microfluidic cell (16microL) under an electric potential (10V), followed by anhydrous MeCN. The trapped [(18)F]fluoride was released in MeCN containing Kryptofix 222-KHCO(3) (ca. 60microL) under heat and a reversed potential (-2.5V). An automated module provided the [(18)F]fluoride ready for subsequent microfluidic radiosynthesis in overall radiochemical yields of 60% within 6min.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disposable Equipment*
  • Electrochemistry / instrumentation*
  • Equipment Design
  • Equipment Failure Analysis
  • Fluorine Radioisotopes / chemistry*
  • Isotope Labeling / instrumentation*
  • Microfluidic Analytical Techniques / instrumentation*
  • Oxygen Isotopes / chemistry
  • Radiopharmaceuticals / chemical synthesis*
  • Radiopharmaceuticals / isolation & purification*

Substances

  • Fluorine Radioisotopes
  • Oxygen Isotopes
  • Radiopharmaceuticals