The purpose of this study was to determine if use of protective behavioral strategies mediated the relationship between conscientiousness and alcohol use and alcohol-related problems. Participants were 186 college students at a state university campus in the Northeastern United States participating in a study examining the effectiveness of a brief alcohol intervention. Data were collected during the 2006-2007 academic years. Results indicated that use of protective behavioral strategies mediated the relationship between conscientiousness and both alcohol use and alcohol-related problems. Implications of the findings for researchers and clinicians in the area of preventing high-risk drinking among college students are discussed.