Abstract
We infected squirrel monkeys (Saimiri sciureus) with Nipah virus to determine the monkeys' suitability for use as primate models in preclinical testing of preventive and therapeutic treatments. Infection of squirrel monkeys through intravenous injection was followed by high death rates associated with acute neurologic and respiratory illness and viral RNA and antigen production.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Viral / blood
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Antigens, Viral / biosynthesis
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Disease Models, Animal*
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Henipavirus Infections / mortality
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Henipavirus Infections / physiopathology*
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Henipavirus Infections / virology
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Humans
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Nipah Virus / genetics
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Nipah Virus / immunology
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Nipah Virus / pathogenicity*
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RNA, Viral / biosynthesis
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Saimiri / virology*
Substances
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Antibodies, Viral
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Antigens, Viral
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RNA, Viral