Malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart: a case report

Masanori Kitamura; Naoki Wada; Shigenori Nagata; Norishige Iizuka; Yu-Fen Jin; Miki Tomoeda; Michiko Yuki; Norifumi Naka; Nobuhito Araki; Chikao Yutani; Yasuhiko Tomita

doi:10.1186/1746-1596-5-2

Malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart: a case report

Diagn Pathol. 2010 Jan 9:5:2. doi: 10.1186/1746-1596-5-2.

Authors

Masanori Kitamura¹, Naoki Wada, Shigenori Nagata, Norishige Iizuka, Yu-Fen Jin, Miki Tomoeda, Michiko Yuki, Norifumi Naka, Nobuhito Araki, Chikao Yutani, Yasuhiko Tomita

Affiliation

¹ Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari, Osaka, Japan.

Abstract

A rare case is presented of a 61-year-old man with a malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart. The primary tumor originated in the right thigh in 1982. Since then, the patient has had repeated local recurrences in spite of repeated surgical treatment and adjuvant chemotherapy. He has developed previous metastases of the lung and heart. The patient died of cardiac involvement.

Publication types

Case Reports
Review

MeSH terms

Amputation, Surgical
Autopsy
Biopsy
Chemotherapy, Adjuvant
Fatal Outcome
Heart Neoplasms / secondary*
Heart Neoplasms / therapy
Humans
Lung Neoplasms / secondary
Lung Neoplasms / therapy
Magnetic Resonance Imaging
Male
Middle Aged
Neoplasm Recurrence, Local
Nerve Sheath Neoplasms / secondary*
Nerve Sheath Neoplasms / therapy
Neurofibromatosis 1 / pathology*
Neurofibromatosis 1 / therapy
Soft Tissue Neoplasms / pathology*
Soft Tissue Neoplasms / therapy
Thigh
Treatment Outcome