Abstract
Portal hypertension (PH) is a complication that may occur in patients with inflammatory bowel disease (IBD). In these patients, the etiology of PH may not be alcoholic or viral cirrhosis (which cause 90% of cases in the general population). Consequently, etiologic study of PH in patients with IBD should always include a wide spectrum of possibilities. Moreover, the development of PH in IBD patients often requires a distinct therapeutic approach to IBD (both medical and surgical) as PH may be a contraindication for some drugs and is a risk factor for surgical morbidity and mortality. We present the cases of two patients with IBD who developed PH and review the most likely causes of PH in IBD, as well as preventive and therapeutic strategies.
Copyright 2009 Elsevier España, S.L. All rights reserved.
Publication types
-
Case Reports
-
English Abstract
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
-
Arthritis, Juvenile / complications
-
Arthritis, Juvenile / drug therapy
-
Ascites / etiology
-
Crohn Disease / complications*
-
Crohn Disease / drug therapy
-
Crohn Disease / physiopathology
-
Female
-
Humans
-
Hypertension, Portal / etiology*
-
Hypertension, Portal / physiopathology
-
Immunosuppressive Agents / adverse effects
-
Immunosuppressive Agents / therapeutic use
-
Inflammatory Bowel Diseases / complications
-
Inflammatory Bowel Diseases / drug therapy
-
Intestinal Pseudo-Obstruction / etiology
-
Liver Cirrhosis / chemically induced
-
Mesalamine / therapeutic use
-
Mesenteric Veins / pathology
-
Methotrexate / adverse effects
-
Methotrexate / therapeutic use
-
Splenomegaly / etiology
-
Thioguanine / therapeutic use
-
Thrombophilia / etiology
-
Varicose Veins / etiology
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Immunosuppressive Agents
-
Mesalamine
-
Thioguanine
-
Methotrexate