Previews. Inhibition as a transplant-mediated therapy: a new paradigm for treating Parkinson's?

Theofanis Karayannis; Gordon Fishell

doi:10.1016/j.stem.2010.02.003

Previews. Inhibition as a transplant-mediated therapy: a new paradigm for treating Parkinson's?

Cell Stem Cell. 2010 Mar 5;6(3):184-5. doi: 10.1016/j.stem.2010.02.003.

Authors

Theofanis Karayannis¹, Gordon Fishell

Affiliation

¹ Smilow Neuroscience Program and the Department Cell Biology, Smilow Research Center, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.

PMID: 20207216
DOI: 10.1016/j.stem.2010.02.003

Abstract

In this issue of Cell Stem Cell,Martínez-Cerdeño and colleagues (2010) transplant interneuron precursors from the MGE into the striatum of a rat model of Parkinson's disease and observe a 5% increase in the endogenous GABAergic interneuron population resulting in behavioral benefits in both lesioned and wild-type animals.